Blar i SINTEF Open på forfatter "Michel, Maurice"
-
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1
Wallner, Olov; Cázares-Körner, Armando; Scaletti, Emma Rose; Masuyer, Geoffrey; Bekkhus, Tove; Visnes, Torkild; Mamonov, Kirill; Ortis, Florian; Lundbäck, Thomas; Volkova, Maria; Koolmeister, Tobias; Wiita, Elisée; Loseva, Olga; Pandey, Monica; Homan, Evert J.; Benítez-Buelga, Carlos; Davies, Jonathan; Scobie, Martin; Warpman Berglund, Ulrika; Kalderén, Christina; Stenmark, Pål; Helleday, Thomas; Michel, Maurice (Peer reviewed; Journal article, 2022)8-oxo Guanine DNA Glycosylase 1 is the initiating enzyme within base excision repair and removes oxidized guanines from damaged DNA. Since unrepaired 8-oxoG could lead to G : C→T : A transversion, base removal is of utmost ... -
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Baquero, Juan Miguel; Benitez-Buelga, Carlos; Rajagopal, Varshni; Zhenjun, Zhao; Torres-Ruiz, Raúl; Müller, Sarah; Hanna, Bishoy Magdi Fekry; Loseva, Olga; Wallner, Olov; Michel, Maurice; Rodriguez-Perales, Sandra; Gad, Helge; Visnes, Torkild; Helleday, Thomas; Benitez, Javier; Osario, Ana (Peer reviewed; Journal article, 2021)The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive ...